BSHXD up-regulates the expression of OPG mRNA and down-regulates the expression of RANKL mRNA. *, P<0.05, **, P<0.01, compared with normal group; △, P<0.05, △△, P<0.01, compared with model group. All data were obtained from three independent experiments. BSHXD, Bushen Huoxue Decoction; OPG, osteoprotegerin; RANKL, receptor activator of nuclear factor-kappa B ligand; HP, hyperphosphate.