Table 3. Levels of pro- and anti-inflammatory cytokines during and after HIPEC surgery.
Cytokines | t1 | t2 | t3 | t4 | t5 | t6 | t7 |
---|---|---|---|---|---|---|---|
CRP (mg/mL) | 7±11 | 6±9 | 8±10 | 17±15 | 55±26 | 113±36 | 154±70 |
IL-1RA (pg/mL) | 557±2,108 | 1,640±3,830 | 4,972±3,149 | 4,026±3,218 | 3,248±2,791 | 487±587 | 271±271 |
IL-6 (pg/mL) | 16±77 | 282±399 | 994±1,314 | 1,973±3,346 | 1,380±2,229 | 157±348 | 50±100 |
IL-10 (pg/mL) | 9±35 | 70±213 | 58±145 | 47±76 | 101±116 | 31±34 | 10±8 |
IL-18 (pg/mL) | 82±51 | 76±37 | 84±40 | 85±41 | 119±61 | 126±79 | 145±96 |
TNFα (fg/mL) | 45±202 | 17±38 | 41±149 | 74±270 | 60±13 | 29±56 | 18±38 |
MCP-1 (pg/mL) | 181±309 | 1,113±2,601 | 1,442±2,132 | 2,613±9,111 | 500±619 | 175±168 | 129±126 |
IL-8 (pg/mL) | 17±57 | 161±164 | 356±453 | 395±575 | 187±311 | 25±42 | 9±10 |
Elastase (ng/mL) | 80±83 | 129±100 | 169±96 | 181±115 | 199±98 | 150±101 | 142±104 |
C5a (ng/mL) | 101±66 | 68±31 | 68±32 | 98±94 | 138±1,106 | 99±63 | 122±76 |
HIPEC, hyperthermic intraoperative intraperitoneal chemotherapy; CRP, C-reactive protein; MCP-1, monocyte chemotactic protein 1.