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. Author manuscript; available in PMC: 2019 Apr 16.
Published in final edited form as: Immunity. 2018 Apr 3;48(4):716–729.e8. doi: 10.1016/j.immuni.2018.03.015

Figure 3. ExKLRG1 Effector CD8+ T cells Express Cytotoxicity, Survival, and Proliferation Molecules at an Intermediate Level.

Figure 3.

(A) Expression of GzmB, T-bet, Ki-67, Bcl-2, and TCF-1 in splenic effector OT-I cell subsets 9–10 days p.i. with LM.

(B) Expression of effector and memory signature genes in splenic OT-I cell subsets 8–11 days p.i. with LM.

(C-E) Time-dependent expression of CX3CR1 and IL-7Rα in OT-I cell subsets in the blood following LM infection.

(F) Normalized ATAC-seq signal profiles across 7 gene loci in splenic naïve and effector OT-I cell subsets (8 days p.i. with LM). Peaks differentially expressed between OT-I cell subsets are highlighted in grey.

Mean ± SEM are shown. * P < 0.05, ** P < 0.01 and *** P < 0.001 (unpaired two-tailed Student’s t-test). Data are representative of 2–3 independent experiments with 4–8 mice (A, C), pooled from 2–3 independent experiments with 3–11 mice per time point (B, D, E), or 2 independent experiments with pooled cells from 2–3 mice (F). See also Figure S3.