Skip to main content
. Author manuscript; available in PMC: 2019 Apr 16.
Published in final edited form as: Immunity. 2018 Apr 3;48(4):716–729.e8. doi: 10.1016/j.immuni.2018.03.015

Figure 4. Developmental Plasticity of Effector CD8+ T cell Subsets Following LM Infection.

Figure 4.

(A) Expression of KLRG1, IL-7Rα and tdTomato in splenic effector OT-I cell subsets 6 days p.i. with LM (pre-transfer) and 22 days post-transfer (day 28 p.i.).

(B) Development of exKLRG1 memory cells (day 28 p.i.) from three different effector OT-I cell subsets 6 days p.i. with LM.

(C) Expression of KLRG1, IL-7Rα, tdTomato, CD62L and CX3CR1 in splenic effector OT-I cell subsets 9 days p.i. with LM (pre-transfer) and 26 days post-transfer (day 35 p.i.).

(D) Development of exKLRG1 memory cells (day 35 p.i.) from three different effector OT-I cell subsets 9 days p.i. with LM.

(E) Expression of CX3CR1 and CD62L in KLRG1+ and exKLRG1 memory cells 26 days post transfer of day 9 Tdpe cells. Host CD8+ T cells served as a control (gray line).

(F) Expression of CX3CR1 and CD62L in exKLRG1 and KLRG1− Reporter− memory cells 26 days post transfer of day 9 Tmpe cells. Host CD8+ T cells served as a control (gray line).

Mean ± SEM are shown. * P < 0.05 and ** P < 0.01 (unpaired two-tailed Student’s t-test). Data are representative of two independent experiments with 3–4 mice. See also Figure S4.