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. 2019 Apr 9;10:343. doi: 10.3389/fneur.2019.00343

Table 2B.

Multivariable regression of 6-months outcomes.

Variable GOSE≤6 (6-months) ACE physical (6-months) ACE cognitive (6-months) ACE sleep (6-months) ACE emotional (6-months)
OR [95% CI] Sig. (p) OR [95% CI] Sig. (p) OR [95% CI] Sig. (p) OR [95% CI] Sig. (p) OR [95% CI] Sig. (p)
AGE
Per-year 1.007 [0.988, 1.026] 0.487 0.016 [−0.005, 0.037] 0.127 −0.003 [−0.016, 0.011] 0.670 0.010 [0.000, 0.019] 0.041 −0.007 [−0.019, 0.005] 0.254
SEX
Male Reference Reference Reference Reference Reference
Female 1.44 [0.76, 2.74] 0.259 0.89 [0.19, 1.60] 0.013 0.08 [−0.38, 0.53] 0.744 0.03 [−0.28, 0.35] 0.838 0.22 [−0.19, 0.62] 0.290
EDUCATION
Per-year 0.90 [0.81, 0.99] 0.036 −0.08 [−0.19, 0.03] 0.147 −0.04 [−0.11, 0.04] 0.313 −0.05 [−0.10, 0.00] 0.035 −0.02 [−0.09, 0.04] 0.475
ED GCS
= 15 Reference Reference Reference Reference Reference
= 13–14 2.27 [1.20, 4.35] 0.012 0.73 [−0.01, 1.46] 0.053 0.49 [0.01, 0.96] 0.044 0.32 [−0.01, 0.65] 0.057 0.47 [0.05, 0.89] 0.029
CT INTRACRANIAL LESION
Absent Reference Reference Reference Reference Reference
Present 1.44 [0.77, 2.70] 0.260 −0.38 [−1.07, 0.30] 0.273 0.32 [−0.12, 0.76] 0.156 −0.37 [−0.67, −0.06] 0.018 −0.17 [−0.57, 0.22] 0.386
CARDIAC–HYPERTENSION HISTORY
Absent Reference Reference Reference Reference Reference
Present 0.53 [0.22, 1.25] 0.145 0.13 [−0.74, 1.01] 0.762 0.01 [−0.55, 0.57] 0.971 −0.15, [−0.53, 0.24] 0.462 0.00 [−0.50, 0.50] 0.987
CARDIAC-STRUCTURAL/ISCHEMIC/VALVULAR HISTORY
Absent Reference Reference Reference Reference Reference
Present 0.99 [0.45, 2.15] 0.972 −0.39 [−1.29, 0.51] 0.396 0.12 [−0.46, 0.71] 0.674 −0.16 [−0.56, 0.24] 0.428 0.22 [−0.29, 0.74] 0.396
GASTROINTESTINAL HISTORY
Absent Reference Reference Reference Reference Reference
Present 1.89 [0.87, 4.11] 0.107 0.61 [−0.27, 1.50] 0.173 0.72 [0.15, 1.29] 0.014 0.37 [−0.02, 0.76] 0.065 0.42 [−0.09, 0.92] 0.106
PULMONARY HISTORY
Absent Reference Reference Reference Reference Reference
Present 0.87 [0.37, 2.03] 0.740 −0.46 [−1.37, 0.45] 0.323 −0.10 [−0.69, 0.49] 0.743 0.18 [−0.22, 0.59] 0.365 −0.54 [−1.06, −0.02] 0.043
PSYCHIATRIC HISTORY
Absent Reference Reference Reference Reference Reference
Present 2.57 [1.38, 4.77] 0.003 1.38 [0.68, 2.09] < 0.001 0.74 [0.28, 1.20] 0.001 0.51 [0.20, 0.83] 0.001 0.93 [0.53, 1.33] < 0.001
HEADACHE/MIGRAINE HISTORY
Absent Reference Reference Reference Reference Reference
Present 1.72 [0.71, 4.13] 0.227 1.81 [0.79, 2.84] 0.001 0.78 [0.12, 1.44] 0.021 0.26 [−0.19, 0.72] 0.259 0.43 [0.16, 1.02] 0.150

Significance set at p < 0.0083. ACE, Acute Concussion Evaluation; CI, confidence interval; CT, computed tomography; ED, emergency department; GCS, Glasgow Coma Scale; GOSE, Glasgow Outcome Scale Extended; OR, odds ratio.