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. 2019 Apr 9;10:745. doi: 10.3389/fimmu.2019.00745

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Copyright © 2019 Amlani, Choi, Tarnopolsky, Brady, Clarke, Garcia-De La Torre, Mahler, Schmeling, Barber, Jung and Fritzler.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Levels and prevalence of anti-NT5c1a antibodies in sporadic inclusion body myositis (sIBM) and other conditions as detected by an addressable laser bead immunoassay based on full-length human recombinant antigen. The cutoff was established at 600 MFU (2 standard deviations above the mean of healthy controls; see dotted line) which provided a diagnostic sensitivity of 48.8% and a specificity of 91.8%. Horizontal bars indicate the mean values for each group. DM, dermatomyositis; HC, healthy controls; IIM, idiopathic inflammatory myopathies; JDM, juvenile dermatomyositis; MFI, median fluorescence intensity/median fluorescence units; NMD, neurological/metabolic disorders; OA, osteoarthritis; RA, rheumatoid arthritis; sIBM, sporadic inclusion body myositis; SjS, Sjögren's syndrome; SLE, systemic lupus erythematosus; SSc, systemic sclerosis.