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. 2019 Apr 15;9:6094. doi: 10.1038/s41598-019-42621-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The origin of replication (Ori) was successfully located in all chromosomes. To demonstrate how we visually located the Ori, we selected the DNA Walk (A,B) and mfold (C,D) analysis of chromosome Pac8 (A,C) and Pac4 (B,D). The DNA Walk shows abrupt changes in base composition bias that are characteristic of Oris, and the mfold analysis shows stem-loop configurations containing T-rich loops that are also characteristics of Oris. For Pac8, the Ori was located at position 4,950, while for Pac4, the Ori was located at position 7,850 (both Oris are denoted by a black box). DNA Walker window size: 50.