Table 2.
Patient | Time from transplant | ANC (K/uL) | Treatment (daily doses) | Neutrophil response to A. fumigatus | |||
---|---|---|---|---|---|---|---|
No compound | With C-016 | ||||||
Neutrophils recruited | %Fungus alive | Neutrophils recruited | %Fungus alive | ||||
#1 | 6 months | 12.24 | Prograf 4 mg, Prednisone 20 mg, MMF 1 g |
222 | 56.6% | 1,648 | 2% |
#2 | 6 years | 1.93 | Prograf 4.5 mg, Prednisone 5 mg, MMF 1 g |
447 | 3.6% | 806 | 0.4% |
#3 | 14 years | 4.58 | Prograf 0.5 mg, Prednisone 2.5 mg, Cell Cept 500 mg |
18 | 61.6% | 1166 | 2% |
#4 | 1 month | 0.95 | Prograf 6 mg, Prednisone 15 mg, Cell Cept 750 mg, Cefepime, Valcyte and Bactrim |
17 | 55.7% | 52 | 29.3% |
#5 | 7 years | 2.47 | Prograf 3 mg, Cell Cept 500 mg, Prednisone 5 mg |
71 | 43.2% | 1496 | 5.1% |
#6 | 3 years | 9.34 | Cyclosporine 125 mg, Cell Cept 500 mg, Prednisone 5 mg |
26 | 53.3% | 1,152 | 0% |
Average Transplant Patients | 133.5 ± 70.4 | 45.67 ± 8.8 | 1,053 ± 233.5 | 6.47 ± 4.6 | |||
Average Healthy Controls | 194.2 ± 100 | 26.1 ± 5.1 | 1,966 ± 158.3 | 0.58 ± 0.2 | |||
Comparison between with and without C-0016 | p = 0.012 | p = 0.006 |