Table 3.

Pearson correlation analysis of total body fat vs. levels of urinary metabolites in HFD and control mice. Pearson correlation coefficient was determined for eleven urinary metabolites with significantly different levels in HFD vs. control mice. Asterisk indicates significant correlation; *P < 0.05 (n = 6).

Metabolite	HFD group		Control group		Pathway
	Pearson correlation coefficient	P value	Pearson correlation coefficient	P value
Dimethylamine	−0.878	0.0214*	0.325	0.529	Choline degradation by gut microbiota
Trimethylamine	−0.886	0.0188*	0.276	0.597
Trigonelline	−0.242	0.644	0.0992	0.852	Nicotinamide metabolism
Alanine	−0.702	0.120	−0.311	0.549	Amino acid metabolism
Creatine	0.675	0.142	−0.469	0.348
trans-Aconitate	−0.775	0.0702	0.375	0.464	TCA cycle
cis-Aconitate	0.0616	0.908	0.236	0.652
2-Hydroxyglutarate	0.503	0.310	−0.296	0.570
Succinate	0.299	0.564	−0.306	0.556
Acetate	−0.238	0.650	−0.671	0.145
Benzoate	0.0264	0.960	−0.292	0.575	Aromatic amino acid degradation by gut microbiota