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. 2019 Apr 15;9:6065. doi: 10.1038/s41598-019-42302-x

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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OSS-activated TGF-β1 stimulated PAI-1 luciferase activity in MLEC and collagen expression in endothelial cells. (A) MLECs were stimulated with OSS or SS or unsheared (US) platelet releasates for 18 hours with and without anti-TGF-β1 neutralizing antibody (AF-101-NA). PAI-1 luciferase activity was measured using luminometer and data were plotted as relative luminescence unit (RLU). (B) HUVECs were stimulated with OSS- or SS-activated platelet releasates or unsheared platelet releasates (US) with and without anti-TGF-β1 antibody for 6 hours, collagen (Col1a1) gene expression was measured by RT-PCR (n = 3–4).