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. 2019 Apr 9;10:731. doi: 10.3389/fimmu.2019.00731

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Copyright © 2019 Xie, Wang, Cheng, Zhao, Liu, Zhu, Chen, Jia, Yang, Wu, Zhang, Liu, Yu, Zhang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic model of DHAV-1 inhibiting type I interferon signaling by hijacking the SOCS3 protein. Overexpression of the SOCS3 protein inhibits the expression of IFNα; in addition, SOCS3 inhibits the expression of the key molecules STAT1 and STAT3 in the downstream JAK-STAT pathway and inhibits the expression of the terminal antiviral protein MX1, ultimately promoting virus replication and indirectly assisting in viral adaptation.