Table 2.
Summary of MICs, amino acid substitutions, deletion mutations in the ramRA intergenic region and gene expression fold changes for the ramA, acrB and ompF.
| MIC(ug/mL) | Amino acid substitutions | Deletion mutations | Gene expression fold change | ||||
|---|---|---|---|---|---|---|---|
| Ciprofloxacin | GyrA | ParC | RamRA | ramA | acrB | ompF | |
| A5-S | 0.015 | 1 | 1 | 1 | |||
| A5-R | 16 | S83Y; D87G | S80R | 1.3 | 2.7 | −2.9 | |
| A-5-HR | 2048 | S83Y; D87G | S80I | 41 nt + 1 mutation | 80 | 6.6 | −7.7 |
| A-7-S | 0.06 | 1 | 1 | 1 | |||
| A-7-R | 16 | S83Y | 11 | 3.6 | −25 | ||
| A-7-HR | 2048 | S83Y; D87G | G78D | 9 nt | 83.3 | 10.2 | −3.8 |
| A-21-S | 0.03 | 1 | 1 | 1 | |||
| A-21-R | 8 | S83Y | 11 nt | 72.2 | 8.3 | −6.7 | |
| A-21-HR | 2048 | S83F; D87G | 12 nt +1 mutation | 205.8 | 14.5 | −16.7 | |
| A-33-S | <0.0009 | 1 | 1 | 1 | |||
| A-33-R | 16 | S83F | 35.8 | 5.6 | −100 | ||
| A-33-HR | 2048 | S83F; D87G | 4 nt | 22.6 | 7.4 | −43.3 | |