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. 2019 Apr 9;9:203. doi: 10.3389/fonc.2019.00203

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Copyright © 2019 Buss, Begnini, Bruinsmann, Ceolin, Sonego, Pohlmann, Guterres, Collares and Seixas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NC-LAP increased Bax/Bcl-2 ratio and led to up-regulation of p21 in T-24 cell line after 6 h of treatment. The gene expression profile was determined by qRT-PCR and data were normalized using GAPDH levels. (A) Proapoptotic (Bax) and Antiapoptotic (Bcl-2) gene expression. (B) p21 expression gene. (C) Expression levels of caspase 3, 8, and 9 after 6 h. Data are represented by the means ± SEM from three independent experiments. The one-way ANOVA with Tukey post-hoc was used to analyze statistical significance. Significance was considered at P < 0.05. Significance was considered at P < 0.05. Different letters indicate significant differences between the means and different symbols (^* and #, asterisk and sharp, respectively) indicates difference in the Bax-Bcl-2 ratio levels between groups.