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. 2019 Apr 9;10:719. doi: 10.3389/fimmu.2019.00719

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Copyright © 2019 Parodi, Favoreel, Candiano, Gaggero, Sivori, Mingari, Moretta, Vitale and Cantoni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NKp44-NKp44L interactions and their role in the recognition of tumor (A) or virus-infected cells (B) by human NK cells. (A) Shows cellular and cell-released NKp44 ligands expressed by tumor cells. (B) Shows viral and viral-regulated NKp44 ligands. Viruses up-regulating/down-regulating NKp44L expression on infected cells are indicated with up and down arrows. Green arrows indicate interactions resulting in NK cell activation, while red arrows indicate inhibition. Black arrows refer to still undefined interactions. MLL5, mixed-lineage leukemia protein-5; PCNA, Proliferating Cell Nuclear Antigen; HSPG, heparan sulfate proteoglycans; NID1, Nidogen-1; PDGF, Platelet-Derived Growth Factor; SDC4, syndecan-4.