Table 1.
Expression of NKp44 ligands in human tissues.
| Ligand (inhib/act NKp44)* | Tissues |
|---|---|
|
PCNAa,b (inhibition through ITIM) |
Nervous system: cerebral and prefrontal cortex, spinal cord, cerebellum |
| Endocrine tissues: adrenal, thyroid, parathyroid, and salivary glands, pancreas | |
| BMe and immune system: B, T, and NK cells, monocytes, BM stromal cells, LNe, tonsil, spleen, appendix | |
| Muscle tissues: heart, smooth and skeletal muscle | |
| Respiratory system: lung, nasopharynx, bronchus | |
| Skeletal system: bone | |
| Digestive system: colon and ileum epithelial cells, colon, esophagus, gallbladder, gut, cardia, liver, oral epithelium, stomach, rectum, duodenum, small intestine | |
| Urinary system: kidney, bladder | |
| Male tissues: testis, seminal vesicle, prostate gland, epididymis | |
| Female tissues: breast, amniocytes, fallopian tube, myometrium, ovary, placenta, uterus, uterine cervix, vagina, endometrium | |
| Adipose and soft tissues: adipocytes | |
| Integumentary system: hair follicle, skin | |
|
21spe-MLL5c (activation) |
BM and immune system: CD4+ T cells from HIV-infected patients |
| Skeletal system: articular chondrocytes | |
|
Syndecan-4a,b (inhibition through receptor masking) |
Nervous system: cerebral and prefrontal cortex, spinal cord, cerebellum, hippocampus, caudate |
| Endocrine tissues: adrenal, thyroid, parathyroid, and salivary glands, pancreas | |
| BM and immune system: platelets, LN, tonsil, spleen, appendix | |
| Muscle tissues: heart, smooth and skeletal muscle | |
| Respiratory system: lung, nasopharynx, bronchus | |
| Skeletal system: bone, chondrocytes | |
| Digestive system: colon, gallbladder, liver, oral epithelium, rectum, small intestine, duodenum, stomach, esophagus | |
| Urinary system: kidney, bladder | |
| Male tissues: testis, seminal vesicle, prostate gland, epididymis | |
| Female tissues: breast, amniocytes, fallopian tube, myometrium, ovary, placenta, uterine cervix, vagina, endometrium | |
| Adipose and soft tissues: adipocytes, fibroblasts | |
| Integumentary system: skin | |
|
PDGF-DDb,d (activation) |
Nervous system: cerebral cortex |
| Endocrine tissues: adrenal and thyroid gland | |
| BM and immune system: LN, tonsil, spleen, appendix | |
| Muscle tissues: heart, smooth muscle | |
| Respiratory system: lung | |
| Digestive system: colon, oral epithelium | |
| Male tissues: seminal vesicle | |
| Female tissues: breast, ovary | |
| Integumentary system: skin | |
|
NID1a,b (inhibition through receptor masking) |
Nervous system: arachnoid cyst, cerebral cortex, prefrontal cortex, spinal cord |
| Endocrine tissues: adrenal, thyroid, and salivary glands, pancreas | |
| BM and immune system: platelets, mesenchymal stem cells, NK cells, LN, tonsil, spleen | |
| Muscle tissues: colon muscle, heart | |
| Respiratory system: lung, nasopharynx | |
| Digestive system: colon, esophagus, gallbladder, gut, cardia, liver, oral epithelium, stomach, rectum; | |
| Urinary system: kidney, bladder | |
| Male tissues: testis, seminal vesicle, prostate gland, epididymis | |
| Female tissues: breast, amniocyte, myometrium, ovary, placenta, uterus, uterine cervix | |
| Adipose and soft tissues: adipocytes | |
| Integumentary system: skin |
*
NKp44-NKp44L interactions can result in a different outcome depending on the ligand: activation or inhibition of NK cell functions.
a
Data obtained from ProteomicsDB.
b
data obtained from The Human Protein Atlas.
d
data obtained from ref (107).
e
BM, bone marrow; LN, lymphnodes.