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. 2019 Apr 9;13:288. doi: 10.3389/fnins.2019.00288

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Copyright © 2019 Tomagra, Picollo, Battiato, Picconi, De Marchis, Pasquarelli, Olivero, Marcantoni, Calabresi, Carbone and Carabelli.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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D2-autoreceptor mediated down-regulation of neuronal firing activity measured by μG-SCD-MEAs and MEAs. (A) Representative recordings from one channel of μG-SCD-MEA. Bottom: potentiometric signals from (A) are visualized on an enlarged scale (black traces). Averaged signals are shown in red. (B) Representative recording from one electrode belonging to a conventional MEA, showing the reduction of the firing frequency and its recovery induced by sulpiride. Bottom: individual (black) and averaged signals (red). (C) Top: the bar histograms represent the mean firing frequency in the three conditions (control, with L-DOPA and with L-DOPA+sulpiride), measured by conventional MEAs. Centre, bottom: the bar histogram shows the mean values of the negative peak amplitude and related statistical significance (^∗p < 0.05), for μG-SCD-MEAs and MEAs, respectively.