Table 1.

Comparison of chromosome aneuploidy identified using karyotype and targeted capture sequencing with seven pregnant women

Sample ID	GA	MW (kg)	Gestation (week + day)	Serum screening	Karyotype	NIPT targeted capture sequencing
						Fetal gender	FF (%)	ATD(X)	Chromosome Z‐valuesa					Result
									Chr13	Chr18	Chr21	ChrX	ChrY
AWD01Y1401479‐1‐51	35	66	21 + 0	NA	T13	Female	19.76	195.32	5.53	0.11	−0.44	0.2	−0.42	T13
AWD01Y1401480‐1‐52	26	55	12 + 2	NA	T18	Female	16.90	149.09	−0.66	3.81	−0.4	−2.68	45.28	T18
AWD01Y1401481‐1‐53	41	50	17 + 1	High risk	T18	Female	18.14	185.02	−0.36	3.68	−0.04	0.39	−0.42	T18
AWD01Y1401482‐1‐54	40	51	23 + 1	ND	T21	Male	18.83	154.08	−0.42	−0.09	4.18	0.27	−0.42	T21
AWD01Y1401483‐1‐55	26	54	18 + 1	High risk	T21	Female	21.24	213.41	−0.48	−0.53	5.41	−5.45	81.56	T21
AWD01Y1401490‐1‐62	25	59	18 + 1	Low risk	45, X	45, X	19.86	239.56	0.11	−0.83	−0.83	−3.6	−0.42	X0
AWD01Y1401491‐1‐63	40	56	17 + 0	High risk	47, XXY	47, XXY	16.32	269.11	0.22	1.56	0.01	0.51	64.15	XXY

GA, gestational age; MW, maternal weight; NA, not available; ND, not detected; FF, fetal fraction; ATD(X), average target depth(X); Chr, chromosome.

^aOnly listed the values of targeted chromosomes.