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. 2019 Feb 6;7(4):e00569. doi: 10.1002/mgg3.569

Figure 3.

Figure 3

Real‐time Quantitative PCR Analysis of Transcript Levels of Three SHH‐Signaling Genes in Lymphoblasts from Patients with XLID. Note that compared to normal control lymphoblasts (n = 3), the transcript levels for all three genes, CREB5, BMP4, NEUROG2 in the SHH‐signaling pathway show a significant increase in lymphoblasts carrying three MED12 mutations (p.N898D; p.R1214C; and p.R1295H) within the LS domain but minimal changes for the mutation, p.R206Q, within the L domain. N1007S is the lymphoblast cell line from the probands of the original Lujan syndrome family(Schwartz et al., 2007). Means ± SEM from the triplicate studies of each lymphoblast cell line were shown. **, p < 0.01; ***, p < 0.001