Figure 2.

Proposed workflow for Prader–Willi syndrome (PWS)‐like phenotype referrals including Ch15 microdeletion droplet digital polymerase chain reaction (ddPCR) based analysis and next‐generation sequencing (NGS). Note: Diagnostic outcomes are highlighted in bold. *Consider other obesity‐related disorders; # PWS may present with atypical clinical features due to recessive disorder if mother is a carrier – consider WGS or WES. **If atypical PWS presentation is present, consider WGS or WES candidate gene studies