Table 5.
IL‐4 haplotype frequencies and the association with the risk of lung cancer
| rs2243250 | rs2227284 | rs2243267 | rs2243270 | rs2243283 | rs2243289 | Freq | Crude analysis | adjusted by age | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR (95% CI) | p a‐value | OR (95% CI) | p b‐value | ||||||||
| 1 | T | T | C | G | C | G | 0.598 | 1.00 | — | 1.00 | — |
| 2 | T | T | C | G | G | G | 0.185 | 0.76 (0.54–1.08) | 0.120 | 0.78 (0.53–1.14) | 0.200 |
| 3 | C | G | G | A | C | A | 0.150 | 0.67 (0.46–0.97) | 0.035 | 0.63 (0.42–0.96) | 0.034 |
| 4 | C | T | G | A | C | A | 0.050 | 0.73 (0.40–1.33) | 0.300 | 0.87 (0.44–1.73) | 0.690 |
| Rare | * | * | * | * | * | * | 0.013 | 0.38 (0.10–1.45) | 0.160 | 0.38 (0.08–1.68) | 0.200 |
OR: odd ratio; 95% CI: 95% confidence interval. The GenBank reference of IL‐4: NC_000005.10.
p a‐values were calculated by Wald test without adjustment.
p b‐values were calculated by Wald test adjusted for age.
*
indicates the rare haplotypes with lower frequencies.