Table 2.
Results of overall and subgroup analyses for MTHFR polymorphisms and glaucoma
| Population | Sample size | Dominant comparison | Recessive comparison | Additive comparison | Allele comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P value | OR (95%CI) | I 2 statistic | P value | OR (95%CI) | I 2 statistic | P value | OR (95%CI) | I 2 statistic | P value | OR (95%CI) | I 2 statistic | ||
| rs1801131 A/C | |||||||||||||
| Overall | 1178/995 | 0.71 | 0.95 (0.70–1.27) | 19% | 0.07 | 1.19 (0.98–1.44) | 21% | 0.13 | 0.87 (0.72–1.04) | 0% | 0.15 | 0.91 (0.79–1.04) | 20% |
| East Asian | 342/206 | 0.97 | 0.98 (0.24–3.96) | 0% | 0.50 | 1.14 (0.78–1.67) | 0% | 0.50 | 0.88 (0.60–1.29) | 0% | 0.55 | 0.91 (0.65–1.25) | 0% |
| West Asian | 295/286 | 0.04 | 0.62 (0.39–0.98) | 0% | 0.003 | 1.91 (1.24–2.94) | 0% | 0.36 | 0.85 (0.60–1.20) | 0% | 0.007 | 0.72 (0.58–0.92) | 0% |
| Caucasian | 383/453 | 0.09 | 1.51 (0.94–2.42) | 0% | 0.99 | 1.00 (0.75–1.32) | 0% | 0.32 | 0.87 (0.65–1.15) | 0% | 0.43 | 1.09 (0.88–1.35) | 0% |
| POAG | 824/669 | 0.80 | 1.05 (0.71–1.56) | 0% | 0.20 | 1.16 (0.93–1.46) | 20% | 0.16 | 0.86 (0.69–1.07) | 0% | 0.40 | 0.93 (0.79–1.10) | 0% |
| PXFG | 232/183 | 0.57 | 1.19 (0.65–2.18) | 0% | 0.68 | 0.92 (0.60–1.40) | 0% | 0.99 | 1.00 (0.65–1.55) | 0% | 0.55 | 1.10 (0.81–1.52) | 15% |
| rs1801133 C/T | |||||||||||||
| Overall | 3453/3715 | 0.04 | 0.90 (0.81–1.00) | 43% | 0.08 | 1.16 (0.98–1.38) | 9% | 0.30 | 1.06 (0.95–1.17) | 28% | 0.02 | 0.91 (0.84–0.98) | 45% |
| East Asian | 970/713 | 0.58 | 0.94 (0.76–1.16) | 22% | 0.74 | 1.05 (0.78–1.42) | 0% | 0.76 | 1.03 (0.84–1.27) | 22% | 0.57 | 0.96 (0.82–1.11) | 0% |
| West Asian | 894/1372 | 0.02 | 0.80 (0.66–0.97) | 20% | <0.001 | 3.07 (1.64–5.76) | 18% | 0.29 | 1.11 (0.91–1.35) | 36% | 0.002 | 0.77 (0.65–0.91) | 25% |
| Caucasian | 1080/1148 | 0.40 | 0.88 (0.65–1.18) | 61% | 0.94 | 1.01 (0.76–1.34) | 0% | 0.99 | 1.00 (0.84–1.19) | 32% | 0.34 | 0.90 (0.71–1.13) | 62% |
| POAG | 2244/2019 | 0.02 | 0.86 (0.76–0.98) | 50% | 0.19 | 1.16 (0.93–1.46) | 2% | 0.13 | 1.10 (0.97–1.26) | 33% | 0.04 | 0.85 (0.73–1.00) | 53% |
| PCAG | 506/902 | 0.35 | 1.13 (0.88–1.45) | 0% | 0.54 | 1.87 (0.25–13.87) | 74% | 0.15 | 0.84 (0.65–1.07) | 0% | 0.76 | 1.03 (0.85–1.25) | 34% |
| PXFG | 703/794 | 0.16 | 0.85 (0.69–1.06) | 44% | 0.45 | 1.15 (0.80–1.64) | 0% | 0.34 | 1.11 (0.89–1.39) | 31% | 0.15 | 0.89 (0.75–1.05) | 33% |
CI, Confidence interval; NA, Not available; OR, Odds ratio; POAG, Primary open‐angle glaucoma; PCAG, Primary closed angle glaucoma; PXFG, Pseudoexfoliation glaucoma.
MTHFR, NCBI Reference Sequence: NG_013351.1
The values in bold represent there are statistically significant differences between cases and controls.