Table 2.
Genotype frequencies of SNPs in CXCR2 between patients and controls and their association with preeclampsia risk
| Genetic model | Genotype | Patients | control | Logistic regression | |
|---|---|---|---|---|---|
| N = 238 (%) | N = 243 (%) | OR (95% CI) | p Value | ||
| rs1126579 | |||||
| Codominant | TT | 65 (27.3%) | 101 (41.6%) | 1.00 (reference) | |
| TC | 135 (56.7%) | 114 (46.9%) | 1.84 (1.23–2.74) | ||
| CC | 38 (16%) | 28 (11.5%) | 2.11 (1.18–3.76) | 0.0039 | |
| Dominant | TT | 65 (27.3%) | 101 (41.6%) | 1.00 (reference) | |
| TC/CC | 173 (72.7%) | 142 (58.4%) | 1.89 (1.29–2.78) | 0.001 | |
| Recessive | TT/TC | 200 (84%) | 215 (88.5%) | 1.00 (reference) | |
| CC | 38 (16%) | 28 (11.5%) | 1.46 (0.86–2.47) | 0.16 | |
| Overdominant | TT/CC | 103 (43.3%) | 129 (53.1%) | 1.00 (reference) | |
| TC | 135 (56.7%) | 114 (46.9%) | 1.48 (1.04–2.12) | 0.031 | |
| Log‐additive | — | — | — | 1.54 (1.17–2.03) | 0.0019 |
| rs2230054 | |||||
| Codominant | CC | 101 (42.4%) | 121 (49.8%) | 1.00 (reference) | |
| TC | 127 (53.4%) | 110 (45.3%) | 1.38 (0.96–2.00) | ||
| TT | 10 (4.2%) | 12 (4.9%) | 1.00 (0.42–2.41) | 0.21 | |
| Dominant | CC | 101 (42.4%) | 121 (49.8%) | 1.00 (reference) | |
| TC/TT | 137 (57.6%) | 122 (50.2%) | 1.35 (0.94–1.93) | 0.11 | |
| Recessive | CC/TC | 228 (95.8%) | 231 (95.1%) | 1.00 (reference) | |
| TT | 10 (4.2%) | 12 (4.9%) | 0.84 (0.36–1.99) | 0.7 | |
| Overdominant | CC/TT | 111 (46.6%) | 133 (54.7%) | 1.00 (reference) | |
| TC | 127 (53.4%) | 110 (45.3%) | 1.38 (0.97–1.98) | 0.076 | |
| Log‐additive | — | — | — | 1.22 (0.89–1.66) | 0.21 |
Bold faced values indicate a significant difference at the 5% level.
CXCR2 gene version number: NG_052975.1.