Table 2.

Summary of all notable cases of cardiac toxicities from immune checkpoint inhibitors (continued)

Authors, year [Ref.]	Age, years, sex	Malignancy	Immune checkpoint inhibitor	Doses prior to cardiac irAE,n	Cardiac and other irAE	Management of cadiac irAE	Outcome
Semper et al., 2016	75, M	Squamous cell carcinoma of lung	Nivo 3 mg/kg	8	Myocarditis	ACE-inhibitors, β-blockers, diuretics, prednisolone (1 mg/kg/day)	Survived
Gibson et al., 2016 [14]	68, F	Lung adeno-carcinoma	Nivo (dose NA)	3	Myocarditis, cardiac conduction abnormalities	IV methylprednisolone and amiodarone infusion	Survived
Mehta et al., 2016 [15]	68, F	Metastatic melanoma	Nivo-Ipi combination (dose NA)	2	Myocarditis	1 mg/kg IV methylprednisolone	Resolved
Zimmer et al., 2016 [16]	Case 1: 73, M	Melanoma	Pembro	1	Myocarditis with cardio myopathy	Prednisolone 1 mg/kg/day oral	Survived
		Case 2: 87, M	Melanoma	Nivo	17 weeks after therapy initiation	Asystole	Prednisolone 125 mg/d i.v.	Survived
		Case 3: 77, M	Melanoma	Pembro	10 weeks after therapy initiation	Stable angina pectoris	Stopped pembro	Survived
Berg et al., 2017 [17]	66, M	Chronic myelomonocytic leukemia	Ipi (dose NA)	1	Acute heart failure with progressive conduction delay, colitis	7-day dexamethasone taper followed by ICU, diuretic, and IV methylprednisolone 1,000 mg/day	Fatal
Behling et al., 2017 [18]	63, M	Metastatic uveal melanoma	Nivo 3 mg/kg	2	Myositis with progressive conduction delay	ICU, IV prednisone 1.5 mg/kg	Fatal
Arangalage et al., 2017 [19]	35, F	Stage IIIc melanoma	Ipi 3 mg/kg, Nivo 1 mg/kg	1	Fulminant myocarditis hyperthyroid, myositis	ICU, IV solumedrol 1 g/day and IVIG followed by ECMO and plasma exchange followed by tacrolimus (target blood level 10–15 ng/mL)	Survived, heart failure resolved
Chauhan et al., 2017 [20]	64, M	Metastatic lung adenocarcinoma	Nivo	1	Myocarditis	Prednisone, heart failure medications	Survived, similar symptoms 1 week after rechallenge with Nivo
Tomita et al., 2017 [21]	61, M	Metastatic lung adenocarcinoma	Nivo	11	Acute coronary syndrome	Stenting of right coronary artery	Survived
Tay et al., 2017 [22]	64, F	Glioblastoma	Temozolo-mide+ Nivo + radiation therapy	2	Myocarditis	IV methylprednisolone 500 mg daily for 3 days f/b Single dose of IV infliximab 5 mg/kg on day 2 Day 8, equine ATGAM therapy	Survived
Fukasawa et al., 2017 [23]	69, F	Metastatic lung adenocarcinoma	Nivo (dose NA)	3	Myocarditis	IV methylprednisolone 1,000 mg for 3 days followed by 1 mg/kg/day	Survived

AED, automated external defibrillator; ATGAM, anti-thymocyte globulin; ECMO, extracorporeal membrane oxygenation; ICU, intensive care unit; irAE, immune-related adverse event; IV, intravenous; IVIG, intravenous immunoglobulin; ipi, ipilimumab; mg/kg, milligram/kilogram body weight; NA, not available; nivo, nivolumab; pembro, pembrolizumab.