Table 4.
Codon-based test of purifying selection for pairwise analysis between sequences previously published [1]
| Group | [A] dS > dN |
[B] dN = dS |
[A]/[A + B] | [A]/[A + B]/ control | χ2 | p value |
|---|---|---|---|---|---|---|
| BD | 193 | 239 | 0.44 | (1.11) | 2.42 | 0.119 |
| MDD | 202 | 296 | 0.40 | (1.01) | 0.03 | 0.85 |
| SZ | 247 | 257 | 0.49 | (1.22) | 9.82 | 0.0017 |
| Control | 297 | 445 | 0.40 | (1.00) | NA | NA |
This effect was calculated using the transitions/transversions bias calculation for mtDNA coding sequences as previously published [1] using samples of DLPFC. The number of subjects for each group: BD = 12, MDD = 15, SZ = 14, control = 36.