Table 6.
Association of an mtDNA variant (A15218G) shows an increased risk for G allele in a meta-analysis of four independent studies (total subjects n = 47,451)
Study population [Ref.] | Schizophrenia, n | Controls,n | OR | p value |
---|---|---|---|---|
Swedish [3] | 4,579 | 5,610 | 0.8 | 0.02 |
UK (WTCCC2) [65] | 3,058 | 5,033 | 2.87 | 4.99E-08 |
Danish [66] | 2,538 | 2,3743 | 1.25 | 0.021 |
USA (dB GAIN) [63] | 1,136 | 1,349 | 1.11 | 0.665 |
Total SZ (n = 11,311) | Total C (n = 35,735) | 1.20 pooled Lower–upper 95%: 1.07–1.35 | 2.15E-03 |