Table 4.

Multivariate Cox regression analyses for predictors of survival with objective response as a time-dependent covariate in the REFLECT trial

Parameter	Multivariate analysis
	HR (95% CI)	p value
Macroscopic portal vein invasion (yes vs. no)	1.366 (1.141–1.636)	0.0007
Baseline AFP (ng/mL) (<200 vs. ≥200)	0.564 (0.483–0.659)	<0.0001
No. of tumor sites at baseline (2 vs. 1)	1.400 (1.180–1.662)	<0.0001
No. of tumor sites at baseline (≥3 vs. 1)	2.024 (1.659–2.469)	<0.0001
Involved tumor in liver (yes vs. no)	1.675 (1.203–2.332)	0.0022
Etiology HBV (yes vs. no)	1.199 (1.031–1.395)	0.0185
Prior procedure for HCC (yes vs. no)	0.844 (0.723–0.986)	0.0323
Treatment (LEN vs. SOR)	0.855 (0.734–0.996)	0.0439
Objective response (yes vs. no)	0.611 (0.490–0.762)	<0.0001

Cited from Kudo et al. [11]. HR, hazard ratio; CI, confidence interval; AFP, α-fetoprotein; HBV, hepatitis Bvirus; HCC, hepatocellular carcinoma; LEN, lenvatinib; SOR, sorafenib.