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Relationship between overall survival hazard ratio (OS HR) and time to progression/progression-free survival HR (TTP/PFS HR) among second-line trials (a) and first-line trials (b). Each trial is represented by a circle, with its size proportional to the number of patients. TTP/PFS HR was more strongly correlated with OS HR in a second-line setting (R = 0.91, p = 0.002) than in a first-line (R = 0.77, p < 0.001) setting on the basis of weighted linear regression (*).
