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Relationship between overall survival hazard ratio (OS HR) and time to progression (TTP) HR among the trials in which tumor progression was assessed by TTP (a) and progression-free survival (PFS) (b). Each trial is represented by a circle, with its size proportional to the number of patients. TTP HR and PFS HR were consistently correlated with OS HR (R = 0.72 and R = 0.70, respectively) on the basis of weighted linear regression (*).
