Table 4.

Neuroimaging features of AARS2‐related leukoencephalopathy and three other common adult‐onset leukodystrophies

Disorder	Pattern of white matter involvement	Findings in the corpus callosum	Atrophy	Symmetry	Unique MRI features
AARS2‐L	Predominantly frontoparietal periventricular	Atrophy in the posterior part	Mild cerebral and cerebellar atrophy	Symmetric	White matter rarefaction
ALSP	Predominantly frontoparietal periventricular	Thinning	Prominent cerebral atrophy	Asymmetric	Calcifications
X‐ALD	Predominantly parieto‐occipital	Atrophy in the splenium	Spinal cord atrophy	Asymmetric	Contrast enhancement
MLD	Predominantly frontal periventricular	Thinning	Cerebral atrophy	Symmetric	Spared U fibers