Table 3.
Substaging of the intermediate stage proposed by the Japanese Society of Transcatheter Hepatic Arterial Embolization [24]
| Intermediate substage | B1 | B2 | B3 |
|---|---|---|---|
| Child Pugh score | 5–6 | 5–8 | 9 |
| 4-of-7-cm criterion | in | in (CP 7–8) | any |
| out (CP 5–8) | |||
| Treatment option | RFA | TACE | HAIC |
| LT | |||
| Alternative | TACE | HAIC | BSC |
| (+RFA) | SOR | ||
| 2-year survival rate | 77.2% | 59.5% | 16.7% |
| Median survival time, months | 40.5 | 28.1 | 13.0 |
CP, Child Pugh; RFA, radiofrequency ablation; TACE, transarterial chemoembolization; HAIC, hepatic arterial infusion chemotherapy; LT, liver transplantation; SOR, sorafenib; BSC, best supportive care.