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. 2019 Mar 5;13(1):118–124. doi: 10.1159/000498913

Fig. 2.

Fig. 2.

Quantification of HPC marker-positive cancer cells in the primary tumor, tumor-invaded vessels, and metastatic nodules. In the primary lesion, the percentage of cancer cells that were EpCAM- or NCAM-positive was 5–10% and 10–20%, respectively. In the cancer-invaded blood vessels, both the ratio of the number of vessels invaded by specific HPC marker-positive cancer cells/the total number of vessels invaded by cancer cells and the ratio of the number of specific HPC marker-positive cancer cells in the vessel/the total number of cancer cells in the vessel were much higher than the corresponding ratios in the primary lesion. In the metastatic lesions, the frequency of EpCAM- or NCAM-positive cancer cells differed according to the tumor, and the bigger tumors tended to include HPC marker-positive cancer cells.