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. 2019 Apr 9;10:169. doi: 10.3389/fendo.2019.00169

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Copyright © 2019 Ratner, Kumaresan and Farb.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Progesterone and PregS differentially modulate whole cell currents induced by GABA, glycine and NMDA. Progesterone (P) (100 μM) potentiates the GABA response (A) and inhibits the glycine (B) response. (C) Dose response curves for progesterone modulation of GABA and glycine currents; enhancement of the GABA response by progesterone occurs over the same concentration range as inhibition of the glycine response. (D) PregS (100 μM) potentiates the NMDA response (normal media [Gly]). (E) PregS and glycine potentiate NMDA response by different mechanisms. (F) In the presence of the maximal concentration (10 μM) of glycine, PregS (100 μM) enhances (179 ± 17.1%; n = 4) the response induced by 30 μM of NMDA; (F) In the presence of near maximal concentration of PregS (100 μM), glycine (10 μM) reversibly potentiates (210 ± 36.5%; n = 4) the NMDA response. (G) Dose response curves for PregS modulation of NMDA and GABA currents. Enhancement of the NMDA response by PregS occurs over the same concentration range as inhibition of the GABA response (Horizontal bar above each trace represents period of drug application) [Modified from Wu et al. (23, 24) with Permission].