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. 2019 Apr 9;10:169. doi: 10.3389/fendo.2019.00169

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Copyright © 2019 Ratner, Kumaresan and Farb.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic illustrating pathways that may underlie pM PregS-induced [Ca²⁺]i and pCREB increases. Diagram illustrates 50 pM PregS-stimulated increase in [Ca²⁺]i via voltage-gated Na+ channels, NMDARs, and Ca²⁺L and 50 pM PregS-induced pCREB increases via synaptic NMDAR and ERK activation. Inhibitors used in the study are in bold. ^*KN93 did not inhibit PregS-induced pCREB increases. [From Smith et al. (48) with Permission].