Table 3.
Stratification analysis of associations between MALAT1 polymorphisms and recurrent miscarriage risk in a southern Chinese population.
| Variable | rs619586 (cases/controls) |
p | OR (95% CI) | p | Adjusted OR (95% CI) | pa | Combined (cases/controls)∗ |
p | OR (95% CI) | p | Adjusted OR (95% CI) | pa | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AA | AG/GG | 0–1 | 2–3 | |||||||||||
| Age, years | ||||||||||||||
| <35 | 150/197 | 37/91 | 0.004 | 0.534 (0.345–0.827) | 0.005 | / | / | 177/241 | 10/47 | <0.001 | 0.290 (0.142–0.589) | <0.001 | / | / |
| 35–40 | 38/65 | 14/27 | 0.756 | 0.887 (0.415–1.896) | 0.757 | / | / | 48/80 | 4/12 | 0.314 | 0.556 (0.170–1.821) | 0.332 | / | / |
| >40 | 6/9 | 3/3 | 0.677 | 1.500 (0.223–10.077) | 0.677 | / | / | 8/11 | 1/1 | 0.831 | 1.375 (0.074–25.433) | 0.831 | / | / |
| No. of abortions/% | ||||||||||||||
| 2–3 | 134/271 | 35/121 | 0.012 | 0.585 (0.381–0.381) | 0.014 | 0.577 (0.375–0.888) | 0.012 | 161/332 | 8/60 | <0.001 | 0.275 (0.128–0.589) | <0.001 | 0.270 (0.126–0.580) | <0.001 |
| 4≥ | 60/271 | 19/121 | 0.219 | 0.709 (0.406–1.240) | 0.228 | 0.723 (0.413–1.266) | 0.256 | 72/332 | 7/60 | 0.116 | 0.538 (0.236–1.225) | 0.140 | 0.549 (0.241–1.253) | 0.155 |
∗The combination of protective genotypes used for the calculation were MALAT1: rs591291CC+rs3200401 CT/TT+rs619586 AG/GG. aAdjusted for age. RM, recurrent miscarriage patients. Statistically significant values are shown in bold (P < 0.05).