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. 2019 Mar 9;11(3):237. doi: 10.3390/v11030237

Figure 5.

Figure 5

Cytokine responses of immunized BALB/c mice serum samples on days 0 (D0) and 28 (D28). (A) IFN-gamma response: the Ad5-N construct was dominant in comparison to other N-expressing ones. (B) IL-2 response: considering the respective backbones, the pCD-N1 construct showed increased potential to elicit this cytokine’s production. (C) IL-4 response: similar to IL-2 response, the pCD-N1 group showed elevated levels. IL-4 was further significant in the BoHV4-∆TK-CCHFV-N group. (D) IL-5 response: identical to IL-4. (E) IL-6 response: the BoHV4-∆TK-CCHFV-N and pCD-N1 groups showed higher levels. (F) IL-10 response: the BoHV4-∆TK-CCHFV-N group showed higher potential for stimulation. (G) IL-13 response: similar to IL-2. (H) TNF-alpha response: by subtracting the respective backbones, it is clear that pCD-N1 was dominant in this kind of response. All data are shown as mean ± SD; * p < 0.05; ** p < 0.01 and *** p < 0.001 versus respective backbones.