Table 1.

An indicative table of GWAS-derived cardiomyopathy related genes studied in zebrafish.

Associated Human Disease	Gene (s)	Zebrafish Genotype	References
Atrial Fibrillation	KCNIP1	High atrial rate	[80]
Long QT Syndrome	KCNH2	Severe repolarization	[81]
Atrial Fibrillation	PRRX1	Atrial action potential duration	[82]
Dilated Cardiomyopathy	HSPB7	Cardiac fibrosis, cardiomegaly and sarcomeric abnormalities	[83]
Congenital Heart Defects	PBX3	Myocardial morphogenesis defects	[84]
Mitral Valve Prolapse	LMCD1, TNS1	Increased atrioventricular regurgitation, moderate reduction in cardiac looping	[86]
Atrioventricular Septal Defect	NFATC1	Cardiac looping defects and altered atrioventricular canal patterning	[87]
Heart Rate Variability	GNG11, SYT10, RGS6, HCN4, NEO1, KIAA1755	Sinoatrial pauses and arrests, cardiac edema and uncontrolled atrial contractions	[88]
Lipid Associated-Cardiomyopathy	APOOP1	Increased the LDL-C levels, increase in the average number of vascular plaques	[95]
Lipid Associated-Cardiomyopathy	PLXND1	Modulate angiogenesis, reduced capacity to store lipid in visceral adipose tissue	[96]
Congenital Cardiomyopathy	KIF20A	Relative tachycardia, red blood cells proximal to the atrium and cardiac edema	[97]