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The mechanisms of anti-prion system action: Although detailed mechanisms are as yet unclear, the Upf proteins appear to compete with filaments for Sup35p monomers or block the ends of growing filaments; Ssb1,2, in facilitating the folding of nascent proteins, prevent Sup35p misfolding; and Btn2p (with Hsp42) collects aggregates at one cellular locus. The mechanism of Hsp104’s antiprion action is discussed in the text.
