Table 2.
The effects of Chaperones on yeast prions.
| Chaperone | Effects | Prions Affected | Refs |
|---|---|---|---|
| Hsp104 | filament cleavage (with Hsp70 and Hsp40) | all amyloid-based yeast prions | [104] |
| Ssa1–4 (Hsp70) | filament cleavage | [PSI+] and [URE3] | [96] |
| Sis1 (Hsp40) | propagation; needed for Hsp104 curing; prevents toxicity | all amyloid-based yeast prions; [PSI+]; strong [PSI+] | [37,100] |
| Swa2 (Hsp40) | propagation | [URE3] | [101] |
| Apj1 (Hsp40) | needed for Hsp104 curing of strong [PSI+] | [PSI+] | [105] |
| Hsp90 | needed for Hsp104 curing; variant selection; propagation | [PSI+], [PIN+], and [URE3] | [101,103,106,107] |
| Sti1 | needed for Hsp104 curing | [PSI+] | [108] |
| Cpr7 | Hsp90 co-chaperone | [URE3] | [103] |
| Fes1 | overproduction curing | [URE3] | [39] |
| Sse1 | propagation: necessary and overproduction curing | [URE3] and [PSI+] | [39,40] |
| Sgt2 | affects Hsp104 curing; induced by prions | [PSI+] and [PIN+] | [109] |