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. 2019 Mar 14;16(6):923. doi: 10.3390/ijerph16060923

Table 6.

Lipinski’s rule of five for ADME analysis of our inhibitors (ligands).

No. Name Lipinski’s Rule of Five Drug-Likeness
Molecular Weight (g/mol) Lipophilicity
(MLog P)
Hydrogen Bond Donors Hydrogen Bond Acceptors No. of Rule Violations
Less than 500 Dalton Less than 5 Less than 5 Less than 10 Less than 2 Violations Lipinski’s Rule Follows
1. Teprotide 1101.26 −3.11 10 13 3: MW > 500,
NH or OH > 5, N or O > 10, 1: MW > 500
No
2. Fosinopril 563.66 3.74 1 7 0 Yes
3. Moexipril 498.57 1.54 2 8 0 Yes
4. Quinapril 438.52 2.17 2 6 0 Yes
5. Lisinopril 405.49 −1.46 4 7 0 Yes
6. Cilizapril 417.50 1.79 2 7 0 Yes
7. Trandolapril 430.54 2.19 2 6 0 Yes
8. Enalapril 376.45 1.32 2 6 0 Yes
9. Ramipril 416.51 1.98 2 6 0 Yes
10. Caprtopril 217.29 0.45 1 3 0 Yes
11. Benzapril 424.49 2.23 2 6 0 Yes
12. Perindopril 368.47 1.36 2 6 0 Yes
13. Allicin 162.27 1.18 0 1 0 Yes