Table 1.
Examples of vulnerable bacterial targets by phage proteins.
| Phage Protein | Length and Size | Host Species | Host Target | Target Process | Reference |
|---|---|---|---|---|---|
| N4 Gp8 | 71 aa/8.1 kDa | Escherichia coli | HolA (DNA polymerase) | Replication | [88] |
| ΦX174 lysis protein | 91 aa/10.6 kDa | Escherichia coli | MraY (PG precursor translocase) | Cell wall synthesis | [89] |
| T7 Gp0.4 | 51 aa/5.8 kDa | Escherichia coli | FtsZ (cell division protein) | Cell division | [90] |
| T7 Gp0.7 a | 359 aa/41.1 kDa | Escherichia coli | RpoC (RNA polymerase) | Transcription | [91] |
| T7 Gp2 | 64 aa/7.2 kDa | Escherichia coli | RpoD (RNA polymerase) | Transcription | [92] |
| T7 Gp5.5 | 99 aa/11.2 kDa | Escherichia coli | H-NS (histone-like protein) | Transcription | [93] |
| T7 Gp5.7 | 69 aa/7.4 kDa | Escherichia coli | RpoS (RNA polymerase) | Transcription | [94] |
| 14-1 Gp12 | 310 aa/33.9 kDa | Pseudomonas aeruginosa | RpoA (RNA polymerase) | Transcription | [95] |
| LUZ19 Gp25.1 b | 116 aa/13.6 kDa | Pseudomonas aeruginosa | RpoC (RNA polymerase) | Transcription | [96] |
| LUZ24 Mip (Gp4) | 46 aa/5.7 kDa | Pseudomonas aeruginosa | MvaT (H-NS-like protein) | Transcription | [97] |
| ΦKZ Dip (Gp37) | 273 aa/30.9 kDa | Pseudomonas aeruginosa | Rne (RNase E degradosome) | RNA degradation | [98] |
| D3112 Tip (Gp5) | 136 aa/14.4 kDa | Pseudomonas aeruginosa | PilB (TFP assembly ATPase) | Motility | [99] |
| 77 ORF104 | 52 aa/6.2 kDa | Staphylococcus aureus | DnaI (DNA primosome) | Replication | [86] |
a T7 gp0.7 is a serine/threonine kinase that phosphorylates RpoC to aid the Gp2 function. T7 gp0.7 also affects multiple host proteins [100]; b LKA1 gp36 and LKD16 gp25b were also identified based on direct interactions with RpoC in the same study.