Otopathogen density in the middle ear of PCV7- and PCV10-vaccinated otitis-prone children with pneumococcal or NTHi OM. Data are presented for each child with an otopathogen detected in their middle ear, with each data point representing an individual child and the horizontal bars depicting the median otopathogen DNA concentration in pg/μL in the middle ear effusion. Circles represent PCV7-vaccinated otitis-prone cases and triangles represent PCV10-vaccinated otitis-prone cases. Statistical analysis was conducted on adjusted data, correcting for age and day-care attendance, ns: not significant. NTHi, nontypeable Haemophilus influenzae; PCV, pneumococcal conjugate vaccine.