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. 2019 Apr 18;19(2):137–150. doi: 10.3727/105221618X15372014086197

Figure 1.

Figure 1

Myeloid protein arginine methyltransferase 1 (PRMT1) knockout mice (MKO) have reduced levels of M2 macrophages and anti-inflammatory cytokines after 3 weeks of alcohol feeding. PRMT1 flox/flox (WT) and PRMT1 flox/flox LysM Cre (MKO) littermates (8–10 weeks old ) were fed Lieber–DeCarli alcohol liquid diet (alcohol), control liquid diet (pair) for 3 weeks, or left on chow diet (chow). (A) Representative images of H&E staining. Scale bars: 100 μm. (B) Serum ALT levels. Data presented as average ± SD, n = 6–10 animals per group. **p < 0.01. (C, D) Liver mRNA levels. n = 4–6 animals per group. *p < 0.05; **p < 0.01. (E) Representative images of PCNA staining. Right: average number of PCNA per 10× field. Data presented as average ± SD, n = 4 animals per group. ***p < 0.001. (F) Liver mRNA levels. n = 4–6 animals per group. *p < 0.05.