Figure 10.

KO and CON mice exposed biweekly to CCl₄ for 8 weeks showed comparable histological injury, repair, and inflammation. Representative sections from KO and CON after 8 weeks of CCl₄ treatment show comparable histology by H&E of some inflammation, fibrosis, and necrosis. Also, representative staining on KO and CON at the same time for PCNA, CD45, and F4/80 show comparable numbers of hepatocytes in the S phase of the cell cycle, comparable immune cell infiltration, and similar numbers and distribution of macrophages, respectively. Quantification of each of these stains verified lack of significant differences between the two groups for any of these markers. Scale bar: 100 μm.