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. 2019 Apr 18;19(2):121–136. doi: 10.3727/105221618X15373858350141

Figure 4.

Figure 4

KO and CON mice subjected to BDL for 7 days show comparable biochemical injury and histology. (A) Schematic showing age- and sex-matched 2.5- to 3-month old KO (n = 5) and CON (n = 6) subjected to 7 days of BDL at which time they were euthanized for serum and liver analysis. (B) Serum biochemistry shows expected abnormally high values of ALP, ALT, AST, direct BR, and total BR at 7 days after BDL, although differences between KO and CON were insignificant. (C) H&E staining showed remarkable ductular reaction and periportal immune cell infiltration in both CON and KO at 7 days after BDL. Scale bar: 100 μm.