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Infection with VACV-WR results in BBB breakdown and elevated levels of MMP-9. Mice were infected i.c. with VACV-Lister (106 pfu, n = 4), VACV-Wyeth (106 pfu, n = 5) or of VACV-WR (102 pfu, n = 5). Perfused brains of VACV-Lister (left; 6 d.p.i), VACV-Wyeth (middle; 5 d.p.i.) and VACV-WR (right; 5 d.p.i.) following Evans-blue peripheral administration (two representative brains from each strain). Blue color represents vasculature dysfunctional leakage, a hallmark of BBB breakdown.
