Table 3.
Multiple linear regression model for the methylation percentages (%) of the CDKN2A, MLH1, and APC genes and the LINE-1 repeat sequence in relation to passive smoking, drinking habit, and ex-smoker status (group case × control).
| Gene | Variable | Β | SD (β) | p Value |
|---|---|---|---|---|
| CDKN2A (n = 101) | Constant | 2.69 | 0.74 | <0.001 * |
| Group (case/control) | 1.14 | 0.61 | 0.06 | |
| Ex-smoker (yes/no) | 0.82 | 0.61 | 0.18 | |
| Passive smoker (yes/no) | 0.23 | 0.6 | 0.7 | |
| Drinking habit | 0.72 | 0.59 | 0.22 | |
| MLH1 (n = 97) | Constant | 2 | 0.55 | <0.001 * |
| Group (case/control) | 1.86 | 0.45 | <0.001 * | |
| Ex-smoker (yes/no) | 0.13 | 0.45 | 0.78 | |
| Passive smoker (yes/no) | −0.07 | 0.44 | 0.88 | |
| Drinking habit | 0.01 | 0.43 | 0.98 | |
| APC (n = 105) | Constant | 3.33 | 0.61 | <0.001 * |
| Group (case/control) | 1.05 | 0.5 | 0.03 * | |
| Ex-smoker (yes/no) | 0.44 | 0.51 | 0.39 | |
| Passive smoker (yes/no) | −0.44 | 0.49 | 0.37 | |
| Drinking habit | 0.16 | 0.49 | 0.74 | |
| LINE-1 (n = 101) | Constant | 67.22 | 0.64 | <0.001 * |
| Group (case/control) | −1.12 | 0.53 | 0.03 * | |
| Ex-smoker (yes/no) | −0.17 | 0.53 | 0.75 | |
| Passive smoker (yes/no) | 0.46 | 0.52 | 0.38 | |
| Drinking habit | 0.69 | 0.51 | 0.18 |
* Statistically significant.