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. 2019 Jan 19;7(1):9. doi: 10.3390/vaccines7010009

Table 3.

Particular vaccine adjuvants or delivery systems used in peptide-based pneumococcal vaccines in pre-clinical studies so far.

Protein Fragment Adjuvant Reference
Pneumococcal surface proteins: CbpD, PhtD, PhtE, ZmpB CbpD_pep4, PhtD_pep19, PhtE_pep40, ZmpB_pep125 and Freund’s adjuvant Papastamatiou et al., 2018 [96]
PspA α1α2 fragment OMVs (Salmonella Outer Membrane Vesicles) Kuipers et al., 2017 [87]
PspA, PdT PspA-PdT fusion protein BCG (Bacillus Calmette-Guérin) Goulart et al., 2017 [103]
PspA, PotD PspA-PotD fusion protein Al(OH)3 Converso et al., 2017 [104]
PspA linear peptides from the PRR or the NPB SVLPs (synthetic Virus-Like Particles) Tamborrini et al., 2015 [90]
PspA, Ply N-terminal fragments of PspA, N-terminal & C-terminal fragments of Ply, fused to an Hbp-carrier OMVs (Salmonella Outer Membrane Vesicles) Kuipers et al., 2015 [86]
Ply, CbpA, PspA combination of full-length or peptide regions of Ply, CbpA, or PspA Alum Chen et al., 2015 [105]
PspA, PspA epitopes from the N-terminal region Aluminum hydroxide Vadesilho et al., 2014 [84]
SP_2108 and SP_0148 lipoproteins 2108- 1912 (fusion construct of SP_2108 and SP_0148) Cholera Toxin (CT)Aluminum hydroxide Moffitt et al., 2014 [113]
PhtD full length PhtD and truncated derivatives (PhtD, PhtD C1, PhtD N2 etc.) E. coli labile toxin B subunit (LTB) Plumptre et al., 2013 [95]
Protein encoded by the spr1875 of R6 strain genome R4-GST fusion protein (glutathione S-transferase) (R4: 161 amino acid-long fragment) Freund’s adjuvant Cardaci et al., 2012 [100]
ZmpB, Ply, Dnal rZmpB, rPly, rDnaJ, rZmpB + rPly, rZmpB + rDnaJ, rPly + rDnaJ, rZmpB + rPly + rDnaJ, Freund’s adjuvant Gong et al., 2011 [98]
PspA N-terminal regions of clades 1,3 and 4 +PRR, N-terminal-PRR, N-terminal+ first block of PRR Al(OH)3 Darrieux et al, 2007 [83]
PspA PR regions and NPB regions (PR+NPB _C, PR+NPB _N, PR+NPB, PR-NPB, or NPB) Alum Daniels et al., 2010 [82]
PspA recombinant N-terminal His- tagged PspA protein cholera toxin B subunit (CTB) King et al., 2009 [89]
PspA Recombinant PspAs TLR-agonists: Pam3 Ultra Pure Escherichia coli K12 LPS, CSK4, Poly(I:C) and Oma et al., 2009 [112]
Several proteins (i.e., PspA, PscB, StkP, PhtD etc) N-terminal two thirds of PcsB, C-terminal half of StkP Alum Giefing et al., 2008 [67]
PspA Six overlapping recombinant fragments of family 2, clade 3 PspA/EF3296 AlOH3 Roche et al., 2003 [125]
PhpA Recombinant PhpA-79 AlPO4 Zhang et al., 2001 [92]
PsaA peptide 43 (palmitoyl residue at the N-terminal end), 46 (same peptide without any ligands, nonlipidated), and PsaA Aluminum hydroxide Srivastava et al., 2000 [99]