Pneumococcal surface proteins: CbpD, PhtD, PhtE, ZmpB |
CbpD_pep4, PhtD_pep19, PhtE_pep40, ZmpB_pep125 and |
Freund’s adjuvant |
Papastamatiou et al., 2018 [96] |
PspA |
α1α2 fragment |
OMVs (Salmonella Outer Membrane Vesicles) |
Kuipers et al., 2017 [87] |
PspA, PdT |
PspA-PdT fusion protein |
BCG (Bacillus Calmette-Guérin) |
Goulart et al., 2017 [103] |
PspA, PotD |
PspA-PotD fusion protein |
Al(OH)3
|
Converso et al., 2017 [104] |
PspA |
linear peptides from the PRR or the NPB |
SVLPs (synthetic Virus-Like Particles) |
Tamborrini et al., 2015 [90] |
PspA, Ply |
N-terminal fragments of PspA, N-terminal & C-terminal fragments of Ply, fused to an Hbp-carrier |
OMVs (Salmonella Outer Membrane Vesicles) |
Kuipers et al., 2015 [86] |
Ply, CbpA, PspA |
combination of full-length or peptide regions of Ply, CbpA, or PspA |
Alum |
Chen et al., 2015 [105] |
PspA, |
PspA epitopes from the N-terminal region |
Aluminum hydroxide |
Vadesilho et al., 2014 [84] |
SP_2108 and SP_0148 lipoproteins |
2108- 1912 (fusion construct of SP_2108 and SP_0148) |
Cholera Toxin (CT)Aluminum hydroxide |
Moffitt et al., 2014 [113] |
PhtD |
full length PhtD and truncated derivatives (PhtD, PhtD C1, PhtD N2 etc.) |
E. coli labile toxin B subunit (LTB) |
Plumptre et al., 2013 [95] |
Protein encoded by the spr1875 of R6 strain genome |
R4-GST fusion protein (glutathione S-transferase) (R4: 161 amino acid-long fragment) |
Freund’s adjuvant |
Cardaci et al., 2012 [100] |
ZmpB, Ply, Dnal |
rZmpB, rPly, rDnaJ, rZmpB + rPly, rZmpB + rDnaJ, rPly + rDnaJ, rZmpB + rPly + rDnaJ, |
Freund’s adjuvant |
Gong et al., 2011 [98] |
PspA |
N-terminal regions of clades 1,3 and 4 +PRR, N-terminal-PRR, N-terminal+ first block of PRR |
Al(OH)3
|
Darrieux et al, 2007 [83] |
PspA |
PR regions and NPB regions (PR+NPB _C, PR+NPB _N, PR+NPB, PR-NPB, or NPB) |
Alum |
Daniels et al., 2010 [82] |
PspA |
recombinant N-terminal His- tagged PspA protein |
cholera toxin B subunit (CTB) |
King et al., 2009 [89] |
PspA |
Recombinant PspAs |
TLR-agonists: Pam3 Ultra Pure Escherichia coli K12 LPS, CSK4, Poly(I:C) and |
Oma et al., 2009 [112] |
Several proteins (i.e., PspA, PscB, StkP, PhtD etc) |
N-terminal two thirds of PcsB, C-terminal half of StkP |
Alum |
Giefing et al., 2008 [67] |
PspA |
Six overlapping recombinant fragments of family 2, clade 3 PspA/EF3296 |
AlOH3
|
Roche et al., 2003 [125] |
PhpA |
Recombinant PhpA-79 |
AlPO4
|
Zhang et al., 2001 [92] |
PsaA |
peptide 43 (palmitoyl residue at the N-terminal end), 46 (same peptide without any ligands, nonlipidated), and PsaA |
Aluminum hydroxide |
Srivastava et al., 2000 [99] |