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Constraint metrics by gene and variant class for H4K20 methyltransferases.
| Gene (HUGO) | Alias | Synonymous (z) | Missense (z) | LoF (pLI) | Associated Disorder |
|---|---|---|---|---|---|
| KMT5A | SETD8 | 0.66 | 2.44 | 0.95 | - |
| KMT5B | SUV420H1 | −0.29 | 2.71 | 1.00 | MR, AD |
| KMT5C | SUV420H2 | −1.82 | 1.99 | 0.69 | - |
