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Bioengineering techniques have resulted in progressively more humanized antibodies. The figure shows the different fractions of the monoclonal antibodies and whether they represent mouse (green) or human (blue) sequences. As the sequences become more humanized their immunogenicity decreases. Glycosylation occurs at amino acid N297 and affects ADCC. Fragment antigen binding (Fab), Fragment crystallizable (Fc), Antigen-dependent cellular cytotoxicity (ADCC).
