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. 2019 Feb 15;7(1):21. doi: 10.3390/vaccines7010021

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Fusion Protein Chimeras. Shown is a diagram of five different versions of mutation stabilized RSV pre-fusion F proteins used in this study. DS-Cav1 protein containing four mutations (red arrows) has been previously described [16] PR-DM and PR-TM are processed (cleaved) F proteins with two or three mutations, respectively, indicated by red arrows. SC-DM and SC-TM are uncleaved with the p27 sequence and cleavage sites deleted and a linker sequence, in blue, inserted. SC- DM and SC-TM also contained two or three mutations, respectively, indicated by red arrows. All Pre-F proteins contained the ectodomain of the RSV fusion protein fused to the foldon sequence (red), the NDV transmembrane (green), and cytoplasmic (purple) domains. Post-F/F protein contained the deletion indicated.